The approach in developing design goals and guidelines derives in part from evidence-based practices (EBP) in autism interventions and in design. Instead of strict adherence to an EBP process, modifications were made due to deficit of empirical research on residential environments for adults on the spectrum. The chapter describes the process undertaken in identifying and assembling the range of research that underlies the design goals and guidelines of subsequent chapters. With an eye toward research integrity as well as relevancy, the approach encompassed both empirical research and reflective practice, including the lived experiences of those on the spectrum. The mechanics of the search and selection process is described in this chapter, and further detailed in the Appendix.