The power of social connections is a contemporary focus of research across world regions. Yet, evidence of challenges to carers’ social relationships remains fragmented and underexplored. We conducted a scoping review of 66 articles to create a state-of-knowledge review of the social consequences of caring. Findings indicate evidence of consequences for relationships with care receivers, with other family members and with broader social networks. Knowledge gaps include changes in relationships across time and in understanding diversity in the types and extent of consequences. Evidence challenges assumptions related to caregiving families and to the sustainability of family care.