The Australian New Zealand Intergenerational Cohort Consortium (ANZ-ICC) brings together three of the longest running intergenerational cohort studies in Australia and New Zealand to examine the extent to which preconception parental life histories (from infancy to parenthood) predict next generation early health and development. The aims are threefold: (1) to describe pathways of advantage that strengthen emotional health and well-being from one generation to the next, (2) to describe pathways of disadvantage that perpetuate cycles of emotional and behavioural problems across generations, and (3) to identify modifiable factors capable of breaking intergenerational cycles. The Victorian Intergenerational Health Cohort Study has followed 1,943 young Australians from adolescence to adulthood across ten waves since 1992, and 1,030 offspring from pregnancy to early childhood since 2006. The Australian Temperament Project Generation 3 Study has followed 2,443 young Australians from infancy to adulthood across 15 waves since 1983, and 1170 offspring from pregnancy to early childhood since 2012. The Dunedin Multidisciplinary Health and Development Study Parenting Study has followed 1,037 young New Zealanders across 15 waves since 1972, and 730 offspring in early childhood since 1994. Cross-cohort replication analyses will be conducted for common preconception exposures and next generation offspring outcomes, while integrated data analysis of pooled data will be used for rare exposures and outcomes. The ANZ-ICC represents a unique collaboration that bridges the disciplines of lifecourse epidemiology, biostatistics, developmental psychology and psychiatry, to study the role of parental preconception exposures on next generation health and development.
Ainsworth, M.S. (1979) Infant–mother attachment, American Psychologist, 34(10): 932–7. doi: 10.1037/0003-066X.34.10.932
Battista, M.-C., Hivert, M.-F., Duval, K. and Baillargeon, J.-P. (2011) Intergenerational cycle of obesity and diabetes: how can we reduce the burdens of these conditions on the health of future generations?, Experimental Diabetes Research, 2011: art. 596060, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205776/.
Belsky, J., Jaffee, S.R., Sligo, J., Woodward, L. and Silva, P.A. (2005) Intergenerational transmission of warm-sensitive-stimulating parenting: a prospective study of mothers and fathers of 3-year-olds, Child Development, 76(2): 384–96. doi: 10.1111/j.1467-8624.2005.00852.x
Bhutta, Z.A., Dean, S.V., Imam, A.M. and Lassi, Z.S. (2011) A systematic review of preconception risks and interventions, Karachi: The Aga Khan University.
Cohn, L.D. and Becker, B.J. (2003) How meta-analysis increases statistical power, Psychological Methods, 8(3): 243–53. doi: 10.1037/1082-989X.8.3.243
Curran, P.J. and Hussong, A.M. (2009) Integrative data analysis: the simultaneous analysis of multiple data sets, Psychological Methods, 14(2): 81–100. doi: 10.1037/a0015914
Dean, S.V., Lassi, Z.S., Imam, A.M. and Bhutta, Z.A. (2014) Preconception care: nutritional risks and interventions, Reproductive Health, 11(Suppl. 3): S1. doi: 10.1186/1742-4755-11-1
Feldman, R. (2007) Parent–infant synchrony and the construction of shared timing; physiological precursors, developmental outcomes, and risk conditions, Journal of Child Psychology and Psychiatry, 48(3/4): 329–54. doi: 10.1111/j.1469-7610.2006.01701.x
Hadar, E., Ashwal, E. and Hod, M. (2015) The preconceptional period as an opportunity for prediction and prevention of noncommunicable disease, Best Practice & Research Clinical Obstetrics & Gynaecology, 29(1): 54–62.
Jack, B.W., Atrash, H., Coonrod, D.V., Moos, M.-K., O’Donnell, J. and Johnson, K. (2008) The clinical content of preconception care: an overview and preparation of this supplement, American Journal of Obstetrics and Gynecology, 199(6, Suppl. B): S266–S279. doi: 10.1016/j.ajog.2008.07.067
Johnson, K., Posner, S.F., Biermann, J., Cordero, J.F., Atrash, H.K., Parker, C.S., Boulet, S. and Curtis, M. (2006) Recommendations to improve preconception health and health care – United States, Morbidity and Mortality Weekly Report, 55(RR-6), Atlanta, GA: Centers for Disease Control.
Lane, M., Zander-Fox, D.L., Robker, R.L. and McPherson, N.O. (2015) Peri-conception parental obesity, reproductive health, and transgenerational impacts, Trends in Endocrinology & Metabolism, 26(2): 84–90. doi: 10.1016/j.tem.2014.11.005
Leacy, F.B., Floyd, S., Yates, T.A. and White, I.R. (2017) Analyses of sensitivity to the missing-at-random assumption using multiple imputation with delta adjustment: application to a tuberculosis/HIV prevalence survey with incomplete HIV-status data, American Journal of Epidemiology, 185(4): 304–15.
Meaney, M.J. (2010) Epigenetics and the biological definition of gene × environment interactions, Child Development, 81: 41–79. doi: 10.1111/j.1467-8624.2009.01381.x
Michael, R. (2011) Family caring and children’s reading and maths skills, Longitudinal and Life Course Studies, 2(3): 301–18.
Moos, M.-K. (2010) From concept to practice: reflections on the preconception health agenda, Journal of Women’s Health, 19(3): 561–7.
Napoli, C., Glass, C.K., Witztum, J.L., Deutsch, R., D’Armiento, F.P. and Palinski, W. (1999) Influence of maternal hypercholesterolaemia during pregnancy on progression of early atherosclerotic lesions in childhood: Fate of Early Lesions in Children (FELIC) study, The Lancet, 354(9186): 1234–41. doi: 10.1016/S0140-6736(99)02131-5
Patton, G.C., Olsson, C.A., Skirbekk, V., Saffery, R., Wlodek, M.E., Azzopardi, P.S., Stonawski, M., Rasmussen, B., Spry, E., Francis, K., Bhutta, Z.A., Kassebaum, N.J., Mokdad, A.H., Murray, C.J.L., Prentice, A.M., Reavley, N., Sheehan, P., Sweeny, K., Viner, R.M. and Sawyer, S.M. (2018) Adolescence and the next generation, Nature, 554: 458–66. doi: 10.1038/nature25759
Patton, G.C., Sawyer, S. and Santelli, J. (2016) Our future: a lancet commission on adolescent health and wellbeing, The Lancet, 387(10036): 2423–78. doi: 10.1016/S0140-6736(16)00579-1
Posner, S.F., Johnson, K., Parker, C.S., Atrash, H.K. and Biermann, J. (2006) The national summit on preconception care: a summary of concepts and recommendations, Maternal and Child Health Journal, 10(Supp. 1): S197–S205. doi: 10.1007/s10995-006-0107-x
Spry, E., Moreno-Betancur, M., Becker, D., Romaniuk, H., Carlin, J.B., Molyneaux, E., Howard, L.M., Ryan, J., Letcher, P., McIntosh, J., Macdonald, J.A., Greenwood, C.J., Thomson, K.C., McAnally, H., Hancox, R., Hutchinson, D.M., Youssef, G.J., Olsson, C.A. and Patton, G.C. (2019) Maternal mental health and infant emotional reactivity: a 20-year two-cohort study of preconception and perinatal exposures, Psychological Medicine, ahead of print: doi: 10.1017/S0033291719000709.
Sroufe, L., Egeland, B., Carlson, E. and Collins, W.A. (2005) The Development of the Person: the Minnesota Study of Risk and Adaptation from Birth to Adulthood, New York: Guilford Press.
Sterne, J.A.C., Hernán, M.A., et al (2016) ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions, BMJ, 355: art. i4919, https://www.bmj.com/content/355/bmj.i4919.
Tierney, J.F., Vale, C., Riley, R., Smith, C.T., Stewart, L., Clarke, M. and Rovers, M. (2015) Individual Participant Data (IPD) meta-analyses of randomised controlled trials: guidance on their use, PLoS Medicine, 12(7): e1001855, https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1001855. doi: 10.1371/journal.pmed.1001855
VanderWeele, T.J. (2015) Explanation in Causal Inference: Methods for Mediation and Interaction, Oxford: Oxford University Press.
Vansteelandt, S. and Daniel, R.M. (2017) Interventional effects for mediation analysis with multiple mediators, Epidemiology, 28(2): 258–65. doi: 10.1097/EDE.0000000000000596
World Health Organization, United Nations Children’s Fund and World Bank Group (2018) Nurturing Care for Early Childhood Development: A Framework for Helping Children Survive and Thrive to Transform Health and Human Potential, Geneva: World Health Organization.
Corresponding author: Professor Craig Olsson, Centre for Adolescent Health, Murdoch Children’s Research Institute, Royal Children’s Hospital, Parkville, Victoria, Australia.
| May 2022 onwards | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 972 | 753 | 27 |
| Full Text Views | 309 | 60 | 0 |
| PDF Downloads | 229 | 40 | 0 |
Institutional librarians can find more information about free trials here