The Australian and New Zealand Intergenerational Cohort Consortium: a study protocol for investigating mental health and well-being across generations

Authors:
Craig A Olsson Deakin University, Australia
Murdoch Children’s Research Institute, Australia

Search for other papers by Craig A Olsson in
Current site
Google Scholar
Close
,
Elizabeth Spry Deakin University, Australia
Murdoch Children’s Research Institute, Australia

Search for other papers by Elizabeth Spry in
Current site
Google Scholar
Close
,
Primrose Letcher University of Melbourne, Australia

Search for other papers by Primrose Letcher in
Current site
Google Scholar
Close
,
Helena McAnally University of Otago, New Zealand

Search for other papers by Helena McAnally in
Current site
Google Scholar
Close
,
Kim Thomson Deakin University, Australia
University of Melbourne, Australia

Search for other papers by Kim Thomson in
Current site
Google Scholar
Close
,
Jacqui Macdonald

Search for other papers by Jacqui Macdonald in
Current site
Google Scholar
Close
,
Chris Greenwood Deakin University, Australia
Murdoch Children’s Research Institute, Australia

Search for other papers by Chris Greenwood in
Current site
Google Scholar
Close
,
George Youssef Deakin University, Australia
Murdoch Children’s Research Institute, Australia

Search for other papers by George Youssef in
Current site
Google Scholar
Close
,
Helena Romaniuk Deakin University, Australia
Murdoch Children’s Research Institute, Australia

Search for other papers by Helena Romaniuk in
Current site
Google Scholar
Close
,
Ella Iosua University of Otago, New Zealand

Search for other papers by Ella Iosua in
Current site
Google Scholar
Close
,
Jude Sligo University of Otago, New Zealand

Search for other papers by Jude Sligo in
Current site
Google Scholar
Close
,
Delyse Hutchinson
University of New South Wales, Australia

Search for other papers by Delyse Hutchinson in
Current site
Google Scholar
Close
,
Jenn McIntosh

Search for other papers by Jenn McIntosh in
Current site
Google Scholar
Close
,
Meredith O’Connor University of Melbourne, Australia
Murdoch Children’s Research Institute, Australia
Australian National University, Australia

Search for other papers by Meredith O’Connor in
Current site
Google Scholar
Close
,
Rob McGee University of Otago, New Zealand

Search for other papers by Rob McGee in
Current site
Google Scholar
Close
,
Ann Sanson University of Otago, New Zealand

Search for other papers by Ann Sanson in
Current site
Google Scholar
Close
,
Robert J Hancox University of Otago, New Zealand
Joint senior authors

Search for other papers by Robert J Hancox in
Current site
Google Scholar
Close
, and
George C Patton University of Melbourne, Australia
Murdoch Children’s Research Institute, Australia
Joint senior authors

Search for other papers by George C Patton in
Current site
Google Scholar
Close
Restricted access
Get eTOC alerts
Rights and permissions Cite this article

The Australian New Zealand Intergenerational Cohort Consortium (ANZ-ICC) brings together three of the longest running intergenerational cohort studies in Australia and New Zealand to examine the extent to which preconception parental life histories (from infancy to parenthood) predict next generation early health and development. The aims are threefold: (1) to describe pathways of advantage that strengthen emotional health and well-being from one generation to the next, (2) to describe pathways of disadvantage that perpetuate cycles of emotional and behavioural problems across generations, and (3) to identify modifiable factors capable of breaking intergenerational cycles. The Victorian Intergenerational Health Cohort Study has followed 1,943 young Australians from adolescence to adulthood across ten waves since 1992, and 1,030 offspring from pregnancy to early childhood since 2006. The Australian Temperament Project Generation 3 Study has followed 2,443 young Australians from infancy to adulthood across 15 waves since 1983, and 1170 offspring from pregnancy to early childhood since 2012. The Dunedin Multidisciplinary Health and Development Study Parenting Study has followed 1,037 young New Zealanders across 15 waves since 1972, and 730 offspring in early childhood since 1994. Cross-cohort replication analyses will be conducted for common preconception exposures and next generation offspring outcomes, while integrated data analysis of pooled data will be used for rare exposures and outcomes. The ANZ-ICC represents a unique collaboration that bridges the disciplines of lifecourse epidemiology, biostatistics, developmental psychology and psychiatry, to study the role of parental preconception exposures on next generation health and development.

  • Ainsworth, M.S. (1979) Infant–mother attachment, American Psychologist, 34(10): 9327. doi: 10.1037/0003-066X.34.10.932

  • Battista, M.-C., Hivert, M.-F., Duval, K. and Baillargeon, J.-P. (2011) Intergenerational cycle of obesity and diabetes: how can we reduce the burdens of these conditions on the health of future generations?, Experimental Diabetes Research, 2011: art. 596060, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205776/.

    • Search Google Scholar
    • Export Citation
  • Belsky, J., Jaffee, S.R., Sligo, J., Woodward, L. and Silva, P.A. (2005) Intergenerational transmission of warm-sensitive-stimulating parenting: a prospective study of mothers and fathers of 3-year-olds, Child Development, 76(2): 38496. doi: 10.1111/j.1467-8624.2005.00852.x

    • Search Google Scholar
    • Export Citation
  • Bhutta, Z.A., Dean, S.V., Imam, A.M. and Lassi, Z.S. (2011) A systematic review of preconception risks and interventions, Karachi: The Aga Khan University.

    • Search Google Scholar
    • Export Citation
  • Cohn, L.D. and Becker, B.J. (2003) How meta-analysis increases statistical power, Psychological Methods, 8(3): 24353. doi: 10.1037/1082-989X.8.3.243

    • Search Google Scholar
    • Export Citation
  • Curran, P.J. and Hussong, A.M. (2009) Integrative data analysis: the simultaneous analysis of multiple data sets, Psychological Methods, 14(2): 81100. doi: 10.1037/a0015914

    • Search Google Scholar
    • Export Citation
  • Dean, S.V., Lassi, Z.S., Imam, A.M. and Bhutta, Z.A. (2014) Preconception care: nutritional risks and interventions, Reproductive Health, 11(Suppl. 3): S1. doi: 10.1186/1742-4755-11-1

    • Search Google Scholar
    • Export Citation
  • Feldman, R. (2007) Parent–infant synchrony and the construction of shared timing; physiological precursors, developmental outcomes, and risk conditions, Journal of Child Psychology and Psychiatry, 48(3/4): 32954. doi: 10.1111/j.1469-7610.2006.01701.x

    • Search Google Scholar
    • Export Citation
  • Hadar, E., Ashwal, E. and Hod, M. (2015) The preconceptional period as an opportunity for prediction and prevention of noncommunicable disease, Best Practice & Research Clinical Obstetrics & Gynaecology, 29(1): 5462.

    • Search Google Scholar
    • Export Citation
  • Jack, B.W., Atrash, H., Coonrod, D.V., Moos, M.-K., O’Donnell, J. and Johnson, K. (2008) The clinical content of preconception care: an overview and preparation of this supplement, American Journal of Obstetrics and Gynecology, 199(6, Suppl. B): S266S279. doi: 10.1016/j.ajog.2008.07.067

    • Search Google Scholar
    • Export Citation
  • Johnson, K., Posner, S.F., Biermann, J., Cordero, J.F., Atrash, H.K., Parker, C.S., Boulet, S. and Curtis, M. (2006) Recommendations to improve preconception health and health care – United States, Morbidity and Mortality Weekly Report, 55(RR-6), Atlanta, GA: Centers for Disease Control.

    • Search Google Scholar
    • Export Citation
  • Lane, M., Zander-Fox, D.L., Robker, R.L. and McPherson, N.O. (2015) Peri-conception parental obesity, reproductive health, and transgenerational impacts, Trends in Endocrinology & Metabolism, 26(2): 8490. doi: 10.1016/j.tem.2014.11.005

    • Search Google Scholar
    • Export Citation
  • Leacy, F.B., Floyd, S., Yates, T.A. and White, I.R. (2017) Analyses of sensitivity to the missing-at-random assumption using multiple imputation with delta adjustment: application to a tuberculosis/HIV prevalence survey with incomplete HIV-status data, American Journal of Epidemiology, 185(4): 30415.

    • Search Google Scholar
    • Export Citation
  • Meaney, M.J. (2010) Epigenetics and the biological definition of gene × environment interactions, Child Development, 81: 4179. doi: 10.1111/j.1467-8624.2009.01381.x

    • Search Google Scholar
    • Export Citation
  • Michael, R. (2011) Family caring and children’s reading and maths skills, Longitudinal and Life Course Studies, 2(3): 30118.

  • Moos, M.-K. (2010) From concept to practice: reflections on the preconception health agenda, Journal of Women’s Health, 19(3): 5617.

    • Search Google Scholar
    • Export Citation
  • Napoli, C., Glass, C.K., Witztum, J.L., Deutsch, R., D’Armiento, F.P. and Palinski, W. (1999) Influence of maternal hypercholesterolaemia during pregnancy on progression of early atherosclerotic lesions in childhood: Fate of Early Lesions in Children (FELIC) study, The Lancet, 354(9186): 123441. doi: 10.1016/S0140-6736(99)02131-5

    • Search Google Scholar
    • Export Citation
  • Patton, G.C., Olsson, C.A., Skirbekk, V., Saffery, R., Wlodek, M.E., Azzopardi, P.S., Stonawski, M., Rasmussen, B., Spry, E., Francis, K., Bhutta, Z.A., Kassebaum, N.J., Mokdad, A.H., Murray, C.J.L., Prentice, A.M., Reavley, N., Sheehan, P., Sweeny, K., Viner, R.M. and Sawyer, S.M. (2018) Adolescence and the next generation, Nature, 554: 45866. doi: 10.1038/nature25759

    • Search Google Scholar
    • Export Citation
  • Patton, G.C., Sawyer, S. and Santelli, J. (2016) Our future: a lancet commission on adolescent health and wellbeing, The Lancet, 387(10036): 242378. doi: 10.1016/S0140-6736(16)00579-1

    • Search Google Scholar
    • Export Citation
  • Posner, S.F., Johnson, K., Parker, C.S., Atrash, H.K. and Biermann, J. (2006) The national summit on preconception care: a summary of concepts and recommendations, Maternal and Child Health Journal, 10(Supp. 1): S197S205. doi: 10.1007/s10995-006-0107-x

    • Search Google Scholar
    • Export Citation
  • Spry, E., Moreno-Betancur, M., Becker, D., Romaniuk, H., Carlin, J.B., Molyneaux, E., Howard, L.M., Ryan, J., Letcher, P., McIntosh, J., Macdonald, J.A., Greenwood, C.J., Thomson, K.C., McAnally, H., Hancox, R., Hutchinson, D.M., Youssef, G.J., Olsson, C.A. and Patton, G.C. (2019) Maternal mental health and infant emotional reactivity: a 20-year two-cohort study of preconception and perinatal exposures, Psychological Medicine, ahead of print: doi: 10.1017/S0033291719000709.

    • Search Google Scholar
    • Export Citation
  • Sroufe, L., Egeland, B., Carlson, E. and Collins, W.A. (2005) The Development of the Person: the Minnesota Study of Risk and Adaptation from Birth to Adulthood, New York: Guilford Press.

    • Search Google Scholar
    • Export Citation
  • Sterne, J.A.C., Hernán, M.A., et al (2016) ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions, BMJ, 355: art. i4919, https://www.bmj.com/content/355/bmj.i4919.

    • Search Google Scholar
    • Export Citation
  • Tierney, J.F., Vale, C., Riley, R., Smith, C.T., Stewart, L., Clarke, M. and Rovers, M. (2015) Individual Participant Data (IPD) meta-analyses of randomised controlled trials: guidance on their use, PLoS Medicine, 12(7): e1001855, https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1001855. doi: 10.1371/journal.pmed.1001855

    • Search Google Scholar
    • Export Citation
  • VanderWeele, T.J. (2015) Explanation in Causal Inference: Methods for Mediation and Interaction, Oxford: Oxford University Press.

  • Vansteelandt, S. and Daniel, R.M. (2017) Interventional effects for mediation analysis with multiple mediators, Epidemiology, 28(2): 25865. doi: 10.1097/EDE.0000000000000596

    • Search Google Scholar
    • Export Citation
  • World Health Organization, United Nations Children’s Fund and World Bank Group (2018) Nurturing Care for Early Childhood Development: A Framework for Helping Children Survive and Thrive to Transform Health and Human Potential, Geneva: World Health Organization.

    • Search Google Scholar
    • Export Citation
Craig A Olsson Deakin University, Australia
Murdoch Children’s Research Institute, Australia

Search for other papers by Craig A Olsson in
Current site
Google Scholar
Close
,
Elizabeth Spry Deakin University, Australia
Murdoch Children’s Research Institute, Australia

Search for other papers by Elizabeth Spry in
Current site
Google Scholar
Close
,
Primrose Letcher University of Melbourne, Australia

Search for other papers by Primrose Letcher in
Current site
Google Scholar
Close
,
Helena McAnally University of Otago, New Zealand

Search for other papers by Helena McAnally in
Current site
Google Scholar
Close
,
Kim Thomson Deakin University, Australia
University of Melbourne, Australia

Search for other papers by Kim Thomson in
Current site
Google Scholar
Close
,
Jacqui Macdonald

Search for other papers by Jacqui Macdonald in
Current site
Google Scholar
Close
,
Chris Greenwood Deakin University, Australia
Murdoch Children’s Research Institute, Australia

Search for other papers by Chris Greenwood in
Current site
Google Scholar
Close
,
George Youssef Deakin University, Australia
Murdoch Children’s Research Institute, Australia

Search for other papers by George Youssef in
Current site
Google Scholar
Close
,
Helena Romaniuk Deakin University, Australia
Murdoch Children’s Research Institute, Australia

Search for other papers by Helena Romaniuk in
Current site
Google Scholar
Close
,
Ella Iosua University of Otago, New Zealand

Search for other papers by Ella Iosua in
Current site
Google Scholar
Close
,
Jude Sligo University of Otago, New Zealand

Search for other papers by Jude Sligo in
Current site
Google Scholar
Close
,
Delyse Hutchinson
University of New South Wales, Australia

Search for other papers by Delyse Hutchinson in
Current site
Google Scholar
Close
,
Jenn McIntosh

Search for other papers by Jenn McIntosh in
Current site
Google Scholar
Close
,
Meredith O’Connor University of Melbourne, Australia
Murdoch Children’s Research Institute, Australia
Australian National University, Australia

Search for other papers by Meredith O’Connor in
Current site
Google Scholar
Close
,
Rob McGee University of Otago, New Zealand

Search for other papers by Rob McGee in
Current site
Google Scholar
Close
,
Ann Sanson University of Otago, New Zealand

Search for other papers by Ann Sanson in
Current site
Google Scholar
Close
,
Robert J Hancox University of Otago, New Zealand
Joint senior authors

Search for other papers by Robert J Hancox in
Current site
Google Scholar
Close
, and
George C Patton University of Melbourne, Australia
Murdoch Children’s Research Institute, Australia
Joint senior authors

Search for other papers by George C Patton in
Current site
Google Scholar
Close

Corresponding author: Professor Craig Olsson, Centre for Adolescent Health, Murdoch Children’s Research Institute, Royal Children’s Hospital, Parkville, Victoria, Australia.

Content Metrics

May 2022 onwards Past Year Past 30 Days
Abstract Views 972 753 27
Full Text Views 309 60 0
PDF Downloads 229 40 0

Altmetrics

Dimensions

Longitudinal and Life Course Studies
An international journal