Longitudinal and Life Course Studies
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The Prospective Epidemiological Research Studies in IrAN (PERSIAN) Birth Cohort protocol: rationale, design and methodology

Authors:
Mohammad Javad Zare SakhvidiUniversity of Medical Sciences, Iran

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Navid DanaeiSemnan University of Medical Sciences, Iran

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Payam DadvandISGlobal, Barcelona, Spain
Universitat Pompeu Fabra (UPF), Spain
CIBER Epidemiología y Salud Pública (CIBERESP), Spain

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Amir Houshang MehrparvarShahid Sadoughi University of Medical Sciences, Iran

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Motahar Heidari-BeniIsfahan University of Medical Sciences, Iran

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Shamsollah NouripourSemnan University of Medical Sciences, Iran

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Habib NikukarShahid Sadoughi University of Medical Sciences, Iran

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Seyede Shahrbanoo DanialiIsfahan University of Medical Sciences, Iran

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Elham SaffariehSemnan University of Medical Sciences, Iran

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Mahmood NoorishadkamShahid Sadoughi University of Medical Sciences, Iran

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Mohammad Mehdi AminIsfahan University of Medical Sciences, Iran

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Majid MirmohammadkhaniSemnan University of Medical Sciences, Iran

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Mohammad Hassan LotfiShahid Sadoughi University of Medical Sciences, Iran

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Ahmad VaezIsfahan University of Medical Sciences, Iran
University of Groningen, The Netherlands

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Seyyed Jalil MirmohammadiShahid Sadoughi University of Medical Sciences, Iran

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Elaheh ZareanIsfahan University of Medical Sciences, Iran

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Mahdieh MojibianShahid Sadoughi University of Medical Sciences, Iran

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Mahin HashemipourIsfahan University of Medical Sciences, Iran

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Omid YaghiniIsfahan University of Medical Sciences, Iran

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Mohammad Sadegh RezaiMazandaran University of Medical Sciences, Iran

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Ali EsmaeiliRafsanjan University of Medical Sciences, Iran

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Alireza FahimzadShahid Beheshti University of Medical Sciences, Iran

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Hamid HakimiRafsanjan University of Medical Sciences, Iran

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Mohammad Reza NavaeifarMazandaran University of Medical Sciences, Iran

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Hamid Ostad EbrahimiRafsanjan University of Medical Sciences, Iran

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Hossein PoustchiTehran University of Medical Sciences, Iran

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Reza MalekzadehTehran University of Medical Sciences, Iran

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Roya KelishadiIsfahan University of Medical Sciences, Iran

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Background:

Birth cohorts are essential for developing evidence-based policies and advancing knowledge on different aspects of the concept of developmental origins of health and diseases (DOHaD). The Prospective Epidemiological Research Studies in IrAN (PERSIAN) is a multicentre cohort in Iran. It is one of the pioneers of DOHaD research in the Middle East and North Africa (MENA) region. This profile provides a brief overview of this birth cohort, focusing on the objectives and design of the study. The main objective of this birth cohort is to evaluate the associations of socio-economic characteristics, lifestyle, diet, environmental exposures and epigenetic factors with outcomes of: pregnancy; mother and child mental and physical health and well-being; child neurodevelopment; and the establishment of chronic disease risk factors.

Methods:

The enrolment of PERSIAN Birth Cohort participants is currently ongoing in five Iranian cities (Isfahan, Yazd, Semnan, Sari and Rafsanjan). We plan to recruit 15,000 mother–offspring pairs, and to follow them for at least ten years. Data collection consists of three consecutive phases: (1) periconception until birth; (2) infancy (0–2 years); and (3) childhood (3–11 years). We are collecting data on both ‘determinants of health’ and ‘health outcomes’. In addition to questionnaires and physical examination, various biological samples, including blood, urine, hair, nail, cord blood and breastmilk are being collected. Growth and neurodevelopment of children will be monitored. Appropriate data analysis schemes will be employed to assess the role of early life factors in health and disease that would facilitate international comparisons.

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Mohammad Javad Zare SakhvidiUniversity of Medical Sciences, Iran

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Navid DanaeiSemnan University of Medical Sciences, Iran

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Payam DadvandISGlobal, Barcelona, Spain
Universitat Pompeu Fabra (UPF), Spain
CIBER Epidemiología y Salud Pública (CIBERESP), Spain

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Amir Houshang MehrparvarShahid Sadoughi University of Medical Sciences, Iran

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Motahar Heidari-BeniIsfahan University of Medical Sciences, Iran

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Shamsollah NouripourSemnan University of Medical Sciences, Iran

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Habib NikukarShahid Sadoughi University of Medical Sciences, Iran

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Seyede Shahrbanoo DanialiIsfahan University of Medical Sciences, Iran

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Elham SaffariehSemnan University of Medical Sciences, Iran

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Mahmood NoorishadkamShahid Sadoughi University of Medical Sciences, Iran

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Mohammad Mehdi AminIsfahan University of Medical Sciences, Iran

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Majid MirmohammadkhaniSemnan University of Medical Sciences, Iran

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Mohammad Hassan LotfiShahid Sadoughi University of Medical Sciences, Iran

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Ahmad VaezIsfahan University of Medical Sciences, Iran
University of Groningen, The Netherlands

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Seyyed Jalil MirmohammadiShahid Sadoughi University of Medical Sciences, Iran

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Elaheh ZareanIsfahan University of Medical Sciences, Iran

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Mahdieh MojibianShahid Sadoughi University of Medical Sciences, Iran

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Mahin HashemipourIsfahan University of Medical Sciences, Iran

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Omid YaghiniIsfahan University of Medical Sciences, Iran

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Mohammad Sadegh RezaiMazandaran University of Medical Sciences, Iran

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Ali EsmaeiliRafsanjan University of Medical Sciences, Iran

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Alireza FahimzadShahid Beheshti University of Medical Sciences, Iran

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Hamid HakimiRafsanjan University of Medical Sciences, Iran

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Mohammad Reza NavaeifarMazandaran University of Medical Sciences, Iran

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Hamid Ostad EbrahimiRafsanjan University of Medical Sciences, Iran

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Hossein PoustchiTehran University of Medical Sciences, Iran

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Reza MalekzadehTehran University of Medical Sciences, Iran

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Roya KelishadiIsfahan University of Medical Sciences, Iran

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