The Prospective Epidemiological Research Studies in IrAN (PERSIAN) Birth Cohort protocol: rationale, design and methodology

Authors:
Mohammad Javad Zare Sakhvidi University of Medical Sciences, Iran

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Navid Danaei Semnan University of Medical Sciences, Iran

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Payam Dadvand ISGlobal, Barcelona, Spain
Universitat Pompeu Fabra (UPF), Spain
CIBER Epidemiología y Salud Pública (CIBERESP), Spain

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Amir Houshang Mehrparvar Shahid Sadoughi University of Medical Sciences, Iran

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Motahar Heidari-Beni Isfahan University of Medical Sciences, Iran

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Shamsollah Nouripour Semnan University of Medical Sciences, Iran

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Habib Nikukar Shahid Sadoughi University of Medical Sciences, Iran

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Seyede Shahrbanoo Daniali Isfahan University of Medical Sciences, Iran

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Elham Saffarieh Semnan University of Medical Sciences, Iran

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Mahmood Noorishadkam Shahid Sadoughi University of Medical Sciences, Iran

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Mohammad Mehdi Amin Isfahan University of Medical Sciences, Iran

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Majid Mirmohammadkhani Semnan University of Medical Sciences, Iran

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Mohammad Hassan Lotfi Shahid Sadoughi University of Medical Sciences, Iran

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Ahmad Vaez Isfahan University of Medical Sciences, Iran
University of Groningen, The Netherlands

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Seyyed Jalil Mirmohammadi Shahid Sadoughi University of Medical Sciences, Iran

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Elaheh Zarean Isfahan University of Medical Sciences, Iran

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Mahdieh Mojibian Shahid Sadoughi University of Medical Sciences, Iran

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Mahin Hashemipour Isfahan University of Medical Sciences, Iran

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Omid Yaghini Isfahan University of Medical Sciences, Iran

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Mohammad Sadegh Rezai Mazandaran University of Medical Sciences, Iran

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Ali Esmaeili Rafsanjan University of Medical Sciences, Iran

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Alireza Fahimzad Shahid Beheshti University of Medical Sciences, Iran

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Hamid Hakimi Rafsanjan University of Medical Sciences, Iran

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Mohammad Reza Navaeifar Mazandaran University of Medical Sciences, Iran

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Hamid Ostad Ebrahimi Rafsanjan University of Medical Sciences, Iran

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Hossein Poustchi Tehran University of Medical Sciences, Iran

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Reza Malekzadeh Tehran University of Medical Sciences, Iran

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Roya Kelishadi Isfahan University of Medical Sciences, Iran

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Background:

Birth cohorts are essential for developing evidence-based policies and advancing knowledge on different aspects of the concept of developmental origins of health and diseases (DOHaD). The Prospective Epidemiological Research Studies in IrAN (PERSIAN) is a multicentre cohort in Iran. It is one of the pioneers of DOHaD research in the Middle East and North Africa (MENA) region. This profile provides a brief overview of this birth cohort, focusing on the objectives and design of the study. The main objective of this birth cohort is to evaluate the associations of socio-economic characteristics, lifestyle, diet, environmental exposures and epigenetic factors with outcomes of: pregnancy; mother and child mental and physical health and well-being; child neurodevelopment; and the establishment of chronic disease risk factors.

Methods:

The enrolment of PERSIAN Birth Cohort participants is currently ongoing in five Iranian cities (Isfahan, Yazd, Semnan, Sari and Rafsanjan). We plan to recruit 15,000 mother–offspring pairs, and to follow them for at least ten years. Data collection consists of three consecutive phases: (1) periconception until birth; (2) infancy (0–2 years); and (3) childhood (3–11 years). We are collecting data on both ‘determinants of health’ and ‘health outcomes’. In addition to questionnaires and physical examination, various biological samples, including blood, urine, hair, nail, cord blood and breastmilk are being collected. Growth and neurodevelopment of children will be monitored. Appropriate data analysis schemes will be employed to assess the role of early life factors in health and disease that would facilitate international comparisons.

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Mohammad Javad Zare Sakhvidi University of Medical Sciences, Iran

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Navid Danaei Semnan University of Medical Sciences, Iran

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Payam Dadvand ISGlobal, Barcelona, Spain
Universitat Pompeu Fabra (UPF), Spain
CIBER Epidemiología y Salud Pública (CIBERESP), Spain

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Amir Houshang Mehrparvar Shahid Sadoughi University of Medical Sciences, Iran

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Motahar Heidari-Beni Isfahan University of Medical Sciences, Iran

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Shamsollah Nouripour Semnan University of Medical Sciences, Iran

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Habib Nikukar Shahid Sadoughi University of Medical Sciences, Iran

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Seyede Shahrbanoo Daniali Isfahan University of Medical Sciences, Iran

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Elham Saffarieh Semnan University of Medical Sciences, Iran

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Mahmood Noorishadkam Shahid Sadoughi University of Medical Sciences, Iran

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Mohammad Mehdi Amin Isfahan University of Medical Sciences, Iran

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Majid Mirmohammadkhani Semnan University of Medical Sciences, Iran

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Mohammad Hassan Lotfi Shahid Sadoughi University of Medical Sciences, Iran

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Ahmad Vaez Isfahan University of Medical Sciences, Iran
University of Groningen, The Netherlands

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Seyyed Jalil Mirmohammadi Shahid Sadoughi University of Medical Sciences, Iran

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Elaheh Zarean Isfahan University of Medical Sciences, Iran

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Mahdieh Mojibian Shahid Sadoughi University of Medical Sciences, Iran

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Mahin Hashemipour Isfahan University of Medical Sciences, Iran

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Omid Yaghini Isfahan University of Medical Sciences, Iran

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Mohammad Sadegh Rezai Mazandaran University of Medical Sciences, Iran

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Ali Esmaeili Rafsanjan University of Medical Sciences, Iran

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Alireza Fahimzad Shahid Beheshti University of Medical Sciences, Iran

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Hamid Hakimi Rafsanjan University of Medical Sciences, Iran

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Mohammad Reza Navaeifar Mazandaran University of Medical Sciences, Iran

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Hamid Ostad Ebrahimi Rafsanjan University of Medical Sciences, Iran

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Hossein Poustchi Tehran University of Medical Sciences, Iran

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Reza Malekzadeh Tehran University of Medical Sciences, Iran

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Roya Kelishadi Isfahan University of Medical Sciences, Iran

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