Birth cohorts are essential for developing evidence-based policies and advancing knowledge on different aspects of the concept of developmental origins of health and diseases (DOHaD). The Prospective Epidemiological Research Studies in IrAN (PERSIAN) is a multicentre cohort in Iran. It is one of the pioneers of DOHaD research in the Middle East and North Africa (MENA) region. This profile provides a brief overview of this birth cohort, focusing on the objectives and design of the study. The main objective of this birth cohort is to evaluate the associations of socio-economic characteristics, lifestyle, diet, environmental exposures and epigenetic factors with outcomes of: pregnancy; mother and child mental and physical health and well-being; child neurodevelopment; and the establishment of chronic disease risk factors.
The enrolment of PERSIAN Birth Cohort participants is currently ongoing in five Iranian cities (Isfahan, Yazd, Semnan, Sari and Rafsanjan). We plan to recruit 15,000 mother–offspring pairs, and to follow them for at least ten years. Data collection consists of three consecutive phases: (1) periconception until birth; (2) infancy (0–2 years); and (3) childhood (3–11 years). We are collecting data on both ‘determinants of health’ and ‘health outcomes’. In addition to questionnaires and physical examination, various biological samples, including blood, urine, hair, nail, cord blood and breastmilk are being collected. Growth and neurodevelopment of children will be monitored. Appropriate data analysis schemes will be employed to assess the role of early life factors in health and disease that would facilitate international comparisons.
Azami-Aghdash, S., Ghojazadeh, M., Dehdilani, N., Mohammadi, M. and Asl Amin Abad, R. (2014) Prevalence and causes of cesarean section in Iran: systematic review and meta-analysis, Iran Journal of Public Health, 43(5): 545–55.
Babaei, M., Mousavi, S., Malek, M., Tosi, G., Masoumeh, Z., Danaei, N. and Gafar, G. (2005) Cancer occurrence in Semnan province, Iran: results of a population-based cancer registry, Asian Pacific Journal of Cancer Prevention, 6(2): 159–64.
Campbell, A. and Rudan, I. (2011) Systematic review of birth cohort studies in Africa, Journal of Global Health, 1(1): 46–58.
Dahlen, H.G., Kennedy, H.P., Anderson, C.M., Bell, A.F., Clark, A., Foureur, M., Ohm, J.E., Shearman, A.M., Taylor, J.Y. et al. (2013) The EPIIC hypothesis: intrapartum effects on the neonatal epigenome and consequent health outcomes, Medical Hypotheses, 80(5): 656–62. doi: 10.1016/j.mehy.2013.01.017
Feng, A., Wang, L., Chen, X., Liu, X., Li, L., Wang, B., Luo, H., Mo, X. and Tobe, R.G. (2015) Developmental Origins of Health and Disease (DOHaD): implications for health and nutritional issues among rural children in China, Bioscience Trends, 9(2): 82–7. doi: 10.5582/bst.2015.01008
GBD 2016 DALYs and HALE Collaborators (2017) Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016, Lancet, 390(10100): 1260–344. doi: 10.1016/S0140-6736(17)32130-X
Gluckman, P.D., Hanson, M.A., Cooper, C. and Thornburg, K.L. (2008) Effect of in utero and early-life conditions on adult health and disease, New England Journal of Medicine, 359(1): 61–73. doi: 10.1056/NEJMra0708473
Godfrey, K.M. and Barker, D.J.P. (2000) Fetal nutrition and adult disease, American Journal of Clinical Nutrition, 71(5): 1344S–52S. doi: 10.1093/ajcn/71.5.1344s
Godfrey, K.M. and Barker, D.J.P. (2001) Fetal programming and adult health, Public Health Nutrition, 4(2B): 611–24. doi: 10.1079/PHN2001145
Grandjean, P. and Landrigan, P.J. (2014) Neurobehavioural effects of developmental toxicity, Lancet Neurology, 13(3): 330–8. doi: 10.1016/S1474-4422(13)70278-3
Hanson, M.A. and Gluckman, P.D. (2008) Developmental origins of health and disease: new insights, Basic & Clinical Pharmacology & Toxicology, 102(2): 90–3.
Kashani-Sabet, F. (1998) Picturing the homeland: geography and national identity in late nineteenth- and early twentieth-century Iran, Journal of Historical Geography, 24(4): 413–30. doi: 10.1006/jhge.1998.0099
Keil, T., McBride, D., Grimshaw, K., Niggemann, B., Xepapadaki, P., Zannikos, K., Sigurdardottir, S.T., Clausen, M., Reche, M. et al. (2010) The multinational birth cohort of EuroPrevall: background, aims and methods, Allergy, 65(4): 482–90. doi: 10.1111/j.1398-9995.2009.02171.x
Kelishadi, R. and Poursafa, P. (2014a) A review on the genetic, environmental, and lifestyle aspects of the early-life origins of cardiovascular disease, Current Problems in Pediatric and Adolescent Health Care, 44(3): 54–72. doi: 10.1016/j.cppeds.2013.12.005
Kelishadi, R. and Poursafa, P. (2014b) The effects of climate change and air pollution on children and mothers’ health, in K.E. Pinkerton and W.N. Rom (eds) Global Climate Change and Public Health, New York: Springer, pp 273–7.
Kelly-Irving, M., Lepage, B., Dedieu, D., Bartley, M., Blane, D., Grosclaude, P., Lang, T. and Delpierre, C. (2013) Adverse childhood experiences and premature all-cause mortality, European Journal of Epidemiology, 28(9): 721–34. doi: 10.1007/s10654-013-9832-9
Kent, A.L. (2012) Developmental origins of health and adult disease: what should neonatologists/paediatricians be considering about the long-term health of their patients?, Journal of Paediatrics and Child Health, 48(9): 730–4. doi: 10.1111/j.1440-1754.2012.02541.x
Kishi, R., Araki, A., Minatoya, M., Hanaoka, T., Miyashita, C., Itoh, S., Kobayashi, S., Ait Bamai, Y., Yamazaki, K., Miura, R. et al. and the members of The Hokkaido Study on Environment and Children’s Health (2017a) The Hokkaido Birth Cohort Study on environment and children’s health: cohort profile – updated 2017, Environmental Health and Preventative Medicine, 22(1): art 46, https://doi.org/10.1186/s12199-017-0654-3.
Kishi, R., Zhang, J.J., Ha, E.H., Chen, P.C., Tian, Y., Xia, Y., Tsuchiya, K.J., Nakai, K., Kim, S., Hong, S.J. et al. (2017b) Birth cohort consortium of Asia: current and future perspectives, Epidemiology, 28(Suppl 1): S19–34.
Li, J., Robinson, M., Malacova, E., Jacoby, P., Foster, J. and van Eekelen, A. (2013) Maternal life stress events in pregnancy link to children’s school achievement at age 10 years, Journal of Pediatrics, 162(3): 483–9. doi: 10.1016/j.jpeds.2012.09.007
Morton, S.M.B., Atatoa Carr, P.E., Grant, C.C., Robinson, E.M., Bandara, D.K., Bird, A., Ivory, V.C., Kingi, T.K., Liang, R., Marks, E.J. et al. (2013) Cohort profile: Growing Up in New Zealand, International Journal of Epidemiology, 42(1): 65–75. doi: 10.1093/ije/dyr206
Poustchi, H., Eghtesad, S., et al. (2017) Prospective epidemiological research studies in Iran (the PERSIAN Cohort Study): rationale, objectives and design, American Journal of Epidemiology, 187(4): 647–55. doi: 10.1093/aje/kwx314
Robinson, M., Mattes, E., Oddy, W.H., Pennell, C.E., van Eekelen, A., McLean, N.J., Jacoby, P., Li, J., De Klerk, N.H., Zubrick, S.R., Stanley, F.J. and Newnham, J.P. (2011) Prenatal stress and risk of behavioral morbidity from age 2 to 14 years: the influence of the number, type, and timing of stressful life events, Development and Psychopathology, 23(2): 507–20. doi: 10.1017/S0954579411000241
Solar, O. and Irwin, A. (2010) A conceptual framework for action on the social determinants of health, Social Determinants of Health Discussion Paper 2, Geneva: World Health Organization.
Townsend, M.L., Riepsamen, A., Georgiou, C., Flood, V.M., Caputi, P., Wright, I.M., Davis, W.S., Jones, A., Larkin, T.A., Williamson, M.J., Grenyer, B.F.S. (2016) Longitudinal intergenerational birth cohort designs: a systematic review of Australian and New Zealand studies, PLoS One, 11(3): e0150491, https://doi.org/10.1371/journal.pone.0150491. doi: 10.1371/journal.pone.0150491
Van den Bergh, B.R.H. (2011) Developmental programming of early brain and behaviour development and mental health: a conceptual framework, Developmental Medicine and Child Neurology, 53(S4): 19–23. doi: 10.1111/j.1469-8749.2011.04057.x
Vrijheid, M., Casas, M., et al. (2012) European birth cohorts for environmental health research, Environmental Health Perspectives, 120(1): 29–37. doi: 10.1289/ehp.1103823
Vrijheid, M., Slama, R., et al. (2014) The human early-life exposome (HELIX): project rationale and design, Environmental Health Perspectives, 122(6): 535–44. doi: 10.1289/ehp.1307204
Xie, D., Liu, Y. and Chen, J. (2011) Mapping urban environmental noise: a land use regression method, Environmental Science & Technology, 45(17): 7358–64. doi: 10.1021/es200785x
Ziari, K.A. and Ghorbani, R. (2017) Analysis of the regional development status and spatial disparities in Yazd Province, Iran, IJSRSET: International Journal of Scientific Research in Science, Engineering and Technology, 3(3): 539–53.
|May 2022 onwards||Past Year||Past 30 Days|
|Full Text Views||135||135||0|