This article advances understanding of the unpaid care–paid work nexus for carers of a person with a disability or illness, or a frail older relative. It examines the relationship between care intensity (measured in terms of both care hours and care strain) and withdrawal from work (measured in terms of both withdrawal of time spent in paid work and withdrawal from career development and progression). The analysis reveals that care strain has a stronger relationship with all dimensions of work withdrawal than care hours. It also reveals that the relationship between care strain and work withdrawal is moderated by a family-supportive work environment. The article sheds new light on the potential role of workplace cultures in mitigating the impacts of work–care conflict.